The Aventine PharmD/PhD team has over 30 years of combined experience in the areas of managed care, medical writing, and economic modeling. We have developed more than 200 dossiers over the past decade.

  • Acute and chronic leukemias
  • Breast, cervical, and ovarian cancers
  • Colorectal cancer
  • Glioblastoma
  • Head and neck cancers
  • Hodgkin lymphoma
  • Lung cancers
  • Multiple myeloma
  • Non-Hodgkin lymphomas
  • Neuroblastoma
  • Pancreatic cancers
  • Prostate cancer
  • Renal cell carcinoma
  • Skin cancers: melanoma, advanced basal cell carcinoma
  • Soft tissue sarcoma: gastrointestinal stromal tumor
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Inflammatory Disease/Inherited Disease

  • Allergic rhinitis
  • Alpha1-antitrypsin deficiency
  • Asthma
  • Atopic dermatitis
  • Chronic obstructive pulmonary disease (COPD)
  • Cystic fibrosis
  • Hemophilia A
  • Huntington’s disease
  • Polyarticular and systemic juvenile idiopathic arthritis
  • Primary immunodeficiencies
  • Psoriasis and psoriatic arthritis
  • Rheumatoid arthritis
  • Sickle-cell anemia
  • Systemic lupus erythematosus
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Neurology/Central Nervous System

  • Abuse-deterrent opioids
  • Acute agitation
  • Adult upper limb spasticity
  • Attention-deficit hyperactivity disorder
  • Bipolar disorder
  • Cervical dystonia
  • Epilepsy
  • Insomnia
  • Migraine
  • Multiple sclerosis
  • Neuropathies
  • Pain management
  • Parkinson’s disease
  • Procedural sedation
  • Pseudobulbar affect
  • Restless legs syndrome
  • Schizophrenia
  • Tardive dyskinesia
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  • Anemia
  • Chemotherapy-induced nausea and vomiting
  • Chronic idiopathic constipation
  • Chronic kidney disease
  • Crohn’s disease
  • Exocrine pancreatic insufficiency
  • Hepatitis B
  • Hepatitis C
  • Hyperphosphatemia
  • Irritable bowel syndrome
  • Liver transplantation
  • Opioid-induced constipation
  • Post-operative nausea and vomiting
  • Renal transplantation
  • Ulcerative colitis
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Women’s Health

  • Endometriosis
  • Hormonal contraception
  • Hormone replacement therapy
  • Infertility
  • Menorrhagia
  • Non-hormonal contraception
  • Postmenopausal osteoporosis
  • Uterine fibroids
  • Vulvovaginal atrophy
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Infectious Disease/Dermatology

  • Acne/rosacea
  • Complicated skin infections
  • COVID-19 vaccine
  • Diabetic neuropathic ulcers
  • Head lice
  • Invasive fungal infections
  • Neutropenic fever
  • Otitis media
  • Pneumonia
  • Pyelonephritis
  • Urinary tract infection (UTI)
  • Wound care
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Endocrinology/Cardiovascular Disease

  • Cardiac transplant
  • Cardiomyopathy
  • Central precocious puberty
  • Congestive heart failure
  • Deep vein thrombosis
  • Diabetes mellitus, Type 2
  • Growth hormone deficiency
  • Hypertension
  • Obesity
  • Pulmonary arterial hypertension
  • Stroke prevention
  • Vasodilatory shock
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Specific Biotechnologies

  • Antibody-drug conjugate technologies
  • Biomarker-driven therapies
  • Biosimilars
  • CAR-T cell therapy
  • Checkpoint inhibitors
  • Colony stimulating factors
  • Digital inhalers and respiratory delivery systems
  • Enzyme-replacement therapies
  • Follow-on biologics
  • Immune modulators
  • Implantable contraceptive devices
  • Monoclonal antibodies
  • Respiratory delivery systems
  • Sustained-release injectable prodrugs
  • Targeted therapies
  • Thermosensitive polymers
  • Vaccine technology
  • Viscosupplements and cartilage repair

Aventine specifically focuses on the development of reimbursement dossiers and US-based pharmacoeconomic modeling designed to scientifically and effectively demonstrate the value of a product to payers for the purpose of achieving optimal product reimbursement. Our team of highly accomplished clinical professionals has years of experience and expertise developing AMCP dossiers and economic models for a wide range of products across diverse disease states and clinical settings. Because our team has past experience evaluating products for reimbursement and formulary inclusion from the payer side of the access equation, we understand the needs of the US payer audience and are able to leverage that knowledge in developing dossiers and models that are fit for purpose. Understanding our payer audience has been a cornerstone to our continued success.


“It [the dossier update] was an amazing refresh where yours and your teams efforts made it read better, clearer, etc. [vs prior non-Aventine version] and it will be much more useful for end readers (ie formulary decision makers!)”

- S.P. – Senior Director, Health Economics and Outcomes Research

“You guys did a fantastic job and it was a pleasure working with you all!”

- M.H. – Vice President, Market Access

“I just want to again express my sincere appreciation for all the work that both of you put in!! I think this is the first time we’ve actually combined 2 indications across 2 teams, so it really has been a herculean feat! Thank you again for your hard work, organization and clear communication which has made this process so smooth for all of us!”

- E.Y. – Senior Scientist, US Medical Affairs

“That is great news to have the final version! Thank you for delivering an outstanding document and BIM to support our launch efforts.  Count me as one of your biggest fans.”

- A.P. – Vice President, Medical Affairs

“Thanks again for doing a fantastic job with the dossier. Always a pleasure to work with such a capable partner. “

- S.F. – Associate Director Medical Information, Managed Markets

“Thanks for the quick turnaround and for all your hard work. The dossier looks great.”

- E.C. – Managed Care Medical Communications

“Great job on the dossier and the BIM. It has been a pleasure working with you on these projects. Thanks for your flexibility, quick turnaround, and timely deliverables!”

- R.I. – Director, Global Health Economic and Outcomes Research

“I think the dossier looks great! I certainly appreciate all of the work you put in on this project!”

- M.O. – Director, Health Economics and Outcomes Research

“Thank you all your efforts and expertise developing and delivering the AMCP Dossier.  Great work!”

- D.S. – Medical Director, Medical Affairs

“You did a great job on the Dossier. Thank you again for your work on this.”

- N.A. – Medical Affairs, Medical Communications and Promotional Review

“You are outperforming the big companies! Thank you very much for your efforts, the dossier is much improved over the previous version from the other vendor.”

- R.D. – Managed Care Medical Communications

“[The dossier] looks great. Thank you for a wonderful & thorough job.”

- C.A. – Associate Director, Medical Science Communications

“I want to again thank you for your consultation! It really helped me lay out a clear recommendation to our leadership team.”

- D.S. – Director, Medical Science Communications

“I was very impressed with the quality of the content of your work! I know this is the first time I have worked with you as a vendor, and I heard great things from my colleagues, but I appreciate your quality writing, attention to detail, and experienced thinking which I have seen in this dossier.”

- K.P. – Managed Care Medical Communications

“THANK YOU! I appreciate your attention to detail – and the holistic approach!”

- K.G. – Director, Medical Affairs

“We definitely want you to do our [dossier] update next year. Your work is great and it’s a pleasure working with nice people like you.”

- C.W. – Associate Director, Medical Information and Scientific Alliances

“These models look great already, kudos to you & your team!”

- G.B. – Senior Manager, Global Health Economics & Outcomes Research

“Thank you for really hustling, Holly. You and your team are OUTSTANDING!”

- M.B.S. – Senior Manager, Global Health Economics and Outcomes Research

“Made it through this great dossier.  Really well done!”

- N.W.- Executive Director, Medical Affairs

“Great work from the Aventine team! I’ve attached consolidated feedback which is very minimal from [our] team.”

- M.W. – Director, Global Outcomes & Evidence

“I can’t thank you enough for all your hard work on the dossier. I very much appreciate your flexibility, promptness, but most importantly the quality of work. It has truly been a pleasure to work with you as well and I look forward to our future collaboration.”

- F.D. – Medical Communications Liason, Medical Affairs

“[Our] data are quite cumbersome, especially with all the post-hocs, so I very much appreciate your hard work and attention to detail on this. Great job!!”

- J.W. – Managed Care Medical Communication

“I truly appreciate your scientific vigor, clear communication, flexibility, and follow through! I look forward to continuing to work with you and the [Aventine] team on future projects.”

- S.L. – Managed Care Medical Communications

“Many thanks for your flexibility to our schedule and business needs.”

- K.K. – Associate Director, Medical Communications

“This model looks great. Always great to be working with such fine professionals and fellow pharmacists!!”

- C.B. – Senior Manager, Strategic Brand Customer Marketing

“I have reviewed the model and think that it looks excellent! Very nice job!!”

- M.O. – Director, Health Economics and Outcomes Research

“This dossier was well-done, and our review team was extremely pleased. Thank you!”

- G.B. – Senior Manager, Global Health Economics & Outcomes Research

“Your response to [our] inquiry exemplifies your contemporary knowledge and rich experience in the field you’ve created with your colleagues over time.”

- P.O. – Senior Vice President, Research and Development

“I’m very glad we have Aventine as a partner!”

- G.B. – Senior Manager, Global Health Economics & Outcomes Research

“Many thanks for your great work! Our colleagues were all impressed by the quality of the work, and many (including me) did not have any extra comments to add. Bravo for the job well-done!”

- G.B. – Senior Manager, Global Health Economics & Outcomes Research

“Nice job!!! I am impressed with the information and the excellent discussion [in the manuscript]!”

- S.S. – Associate Professor of Pharmacotherapy

“I will always recommend you! You are awesome and a rock star!”

- M.P. – Associate Director, Medical Information

“It was really nice working with you on the dossier. Hope to work with you again in the future.”

- K.K. – Medical Information & Review Analyst

“The BIM looks good and I agree with your logic! Thanks!”

- M.T. – Manager, Health Economics & Outcomes Research

“You always exceed my expectations, thank you!”

- B.G. – Senior Manager, Global Health Economics & Outcomes Research

“Thank you! And the entire Aventine Consulting team for the excellent work! Smooth and easy to work with – as always! I will be in touch regarding the next project as soon as I get approval to move ahead.”

- C.W. – Senior Director, Medical Information and Communication

“I enjoyed our discussion today and I am thrilled to be working with such a talented and experienced team on this important project.”

- D.S. – Medical Director, Medical Affairs

“Thank you for your collaboration! It was great working with you to update the [product] dossier…I appreciate your patience and flexibility.”

- S.Q. – Managed Care Medical Communications

“I also want to provide some extremely positive feedback to you and your team.  As previously discussed, we needed to provide an early draft copy to our partners…to assist their efforts and support for our Compendia application.  They have someone on their team who is reported to be the most experienced “expert” on all matters related to the Compendia, not currently employed there, having over 20 years of prior experience working for the Compendia.  Likewise, in both roles, she has reviewed more than a few dossiers over the years.   She provided great praises and compliments to the dossier draft related to the quality of writing, flow, content, appropriate length, and lack of fluff, noting it was one of the best dossiers she had seen.   Thank you for providing such a high quality document.  The final graphics will enhance the look, but you’ve already hit a homerun on the content!!  THANK YOU!”

- A.P. – VP, Medical Affairs

“Simple, yet concise, complete and compelling!  You make my job easier and I can’t wait for today’s presentation!”

- I.T. – VP, Patient Access & Quality

“The US (and Canadian documents) are well done and feedback from the team has been very positive.”

- R.Y. – Medical Information Specialist